Here is one extraordinary fact: there is no discernible differences between highly malignant cancer cells and certain pre-embryonic cells that are quite normal in the early stages of pregnancy. In technical terms, these normal cells are called trophoblasts.
Effectively cancer and trophoblasts are in fact one and the same.The trophoblast in pregnancy does exhibit all the classical characteristics of cancer. It spreads and multiplies rapidly as it eats its way into the uterus wall, preparing a place where the embryo can attach itself for maternal protection and nourishment.
The trophoblast is formed as a result of a chain reaction starting with another cell, identified as the diploid totipotent. For our purposes, let's call this simply the total life cell, because it contains within it all the separate characteristics of the complete organism, and has the total capacityto evolve into any organ or tissue, or for that matter, into the complete embryo itself.
About 80% of these total life cells are located in the ovaries or testes, where they serve as a genetic reservoir for future offspring. The rest of them are distributed elsewhere in the body, for a purpose involving the regenerative or healing process of damaged tissue.
The hormone estrogen is well-known for its ability to effect changes in living tissue. Although it's generally thought of as a female hormone, it's found in both sexes and performs many vital functions. Wherever the body is damaged, either by physical trauma, chemical actions, or illness, estrogen always appears in great quantities, serving as a stimulator or catalyst for body repair. It's known that the total life cell is triggered into producing trophoblast when it comes into contact with estrogen. When this happens to those total life cells that have evolved from the fertilized egg, the result is a placenta and umbilical cord, a means of nourishing the embryo.
But when it occurs non-sexually, as part of the general healing process, the result is cancer. When cancer begins to form, the body reacts by attempting to seal it off and surrounding it with cells that are similar to those in the location where it occurs. A bump or a lump is the usual result. Under microscopic examination, most of these tumors are found to resemble a mixture or hybrid of both trophoblast and surrounding cells, a fact which has led many researchers to the premature conclusion that there are many different types of cancer.
The degree to which various tumors appear to be different is the same degree to which they're benign, which means that it's the degree to which there are non-cancerous cells within it. The greater the malignancy, the more these tumors begin to resemble each other, and the more clearly they begin to take on the classic characteristics of pregnancy trophoblast.
The most malignant of all cancers, the chorion epitheliomas, are almost indistinguishable from trophoblast cells. They are one and the same. Let's now talk about defense mechanisms. Before we can hope to conquer cancer, first we must understand how nature conquers cancer. How nature protects the body and controls the growth of trophoblast cells. All animals contain billions of white blood cells. One of the functions of these cells is to attack and destroy anything that is foreign and harmful to our bodies. For this reason, it would seem logical that they would attack cancer cells also.
Since cancer is trophoblast and since trophoblast is not foreign to the body, but is in fact a vital part of the life cycle, nature has provided it with a very effective means of avoiding the white cells. One of the characteristics of the trophoblast is that it's surrounded by a thin protein coating that carries a negative electrostatic charge. The white cells also have a negative charge, and since similar polarities repel each other, the trophoblast is well protected.
Part of the solution to this problem is found in the pancreas, which secretes an enzyme called trypsin. When this enzyme reaches the trophoblast in sufficient quantity, it digests the protective protein coat. The cancer then is exposed to the attack of the white cells, and it dies.
To effectively treat cancer and accomplish it with no damage to normal healthy cells, the above targets unique to cancer cells must be identified (The NuCell Program).
Off-target damage limits the utility of conventional chemotherapy and radiation. So called targeted therapies target specific cell signalling pathways but affect normal cells as well as cancer cells. The preferred and ideal cancer therapy should target only cancer cells while causing no harm to normal cells or raising the risk for second cancers.
Our cells are a hybrid composed of a main cell and hundreds of mitochondria which are essentially bacterium. Mitochondria contain their own DNA encoding 37 genes largely responsible for energy metabolism. There is crosstalk between nuclear and mitochondrial DNA. Mitochondria regulate apoptosis (natural programmed cell death) and for this reason alone are a primary target in cancer therapy.
Mitochondria are metabolic engines generating the majority of ATP (energy) within a normal cell. Cancer cells exhibit abnormal energy metabolism due to dysfunctional mitochondria. There are two distinct energy generating systems in the mitochondria, the Tricarboxylic Acid (TCA) cycle and the Electron Transport Chain (ETC). The ETC system produces the majority of the energy within a normal cell through a series of reactions called oxidative phosphorylation (OxPhos). Oxygen is consumed in these reactions.
The mitochondria in cancer cells are damaged and dysfunctional locking the cell in an endless replication process. Causing further damage to already damaged mitochondria releases the signals for apoptosis. Many natural compounds are available to induce the necessary level of mitochondrial damage to only cancer cells while sparing normal healthy cells. Overwhelming the cancer cell with oxidative stress accomplishes the task of triggering apoptosis. Cancer cells are already under a very high oxidative stress level due to their altered metabolism and mitochondrial dysfunction.
A little extra oxidative stress pushes the cancer cell over the cliff and it self destructs. Hydrogen peroxide is an example of an agent capable of inducing excess oxidative stress. Sodium selenite is another. Most natural ant-cancer agents generate reactive oxygen species (ROS) within cancer cells which will surely trigger apoptosis.
The Nucell Program is combinations of agents directly targeting mitochondrial functioning. Normal cells are unaffected because of a much lower oxidative stress baseline.